Clomid (Clomiphene citrate is a drug used during post-cycle-therapy to fend off gynocomastia as well as to raise the body’s natural testosterone levels. There are a few side effects associated with heavy prolonged use, such as vision issues. Clomid is still an effective and inexpensive compound for post-cycle-therapy.
Clomid is not an anabolic steroid rather a prescription drug generally prescribed to women to aid fertility due to its pronounced ability to stimulate ovulation. This is due to it blocking or minimizing the effects of estrogen in the body. Clomid is a synthetic estrogen with both agonist/antagonist properties, and is very similar to its near distant cousin Nolvadex. It can block the ability of estrogen to bind to the estrogen receptor. It is used clinically to oppose the negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, which allows the enhancement and the release of LH and FSH. This results in assistance to induce ovulation.
In men the elevation in both follicle stimulating hormone (FSH) and first and foremost luteinizing hormone (LH) it will ultimately cause natural testosterone production to increase. The effect is beneficial to the athlete at the closing/end of a steroid cycle where endogenous testosterone levels are severely depressed. If endogenous testosterone levels are not returned to normal and acceptable levels, a loss in size, muscle tone and strength is likely to occur once the anabolic levels in the body have dissipated. Without testosterone or other androgens, the catabolic hormone cortisol negatively affects muscle protein synthesis which brings about about a catabolic metabolism.
Male users generally find that a daily intake of 50-100 mg (1-2 tablets) over a four to six week period will bring testosterone production back to what can be perceived as an acceptable testosterone level. Many prefer to combine Clomid with HCG (Human Chorionic Gonadotropin) for the first week or two after anabolic steroids have ceased to be used. HCG helps to restore the ability for the testes to respond and react to endogenous LH, which can be hindered for some time after the cycle is completed. Once the HCG is stopped the user should continue treatment with Clomid alone. HCG should never be used for longer than two to three weeks which results in increased testosterone and estrogen levels may end up initiating the negative feedback inhibition at the hypothalamus in the brain.
Clomid and HCG are also occasionally also incorporated during a steroid cycle in an effort to prevent reducing natural testosterone levels. In many instances this practice can prove difficult however, especially when using strong androgens for longer periods of time.
The most commonly used drug alongside Clomid/Nolvadex is Proviron, an oral DHT-derivative which is used to lower aromatase activity and raise the androgen:estrogen ratio. The Clomid, Nolvadex and Proviron combination is extremely effective for PCT purposes, although it is possible to replace them both with more specific aromatase inhibitors such as Arimidex, Femara, or Aromasin.
Clomid is considered a very safe drug from a toxicity and side-effect purpose. Possible side effects include hot flashes, nausea, dizziness, headaches and temporarily blurred vision.
Water retention: No
High blood pressure: Rare
Liver toxic: Low
DHT Conversion: No
Decreased HPTA function: No, used to stimulate it
Active life: 5-7 days
Drug class: Selective Estrogen Receptor Modulator (Oral)
Average dose: 50 - 100 mg/day