Proviron is the brand name for the orally applicable androgen and DHT (dihydrotestosterone) derivative called Mesterolone. DHT plays a major role in the formation of the male sex organs and in adults, it acts as the primary androgen in the prostate and hair follicles. Proviron has no aromatization properties. It's generally prescribed by doctors to men with low libido as it's a precursor to TRT (testosterone replacement therapy).
Proviron was popularized years ago as an anti-estrogen because it is has a high affinity to bind to the aromatase enzyme, so users could use it to serve as their AI (aromatase inhibitor) replacement. Bodybuilders were using it during post cycle therapy (PCT); unfortunately, studies have shown high dose or long term use of Proviron does suppress LH (luteinizing hormone) and can prevent the pituitary gland from recovering post cycle. Proviron binds very well to SHBG (sex hormone binding globulin), which is the hormone responsible for reducing free testosterone circulating in the body. One of the reasons why some use Proviron during PCT.
Aromasin, Arimidex, and Letrozole, have rendered Proviron obsolete as an anti-estrogen. These are all true aromatase inhibitors (AI) which are safe to use during post cycle therapy, and will not suppress your HPTA. Competitive athletes will appreciate Proviron's hardening properties and since Proviron is 5-alpha reduced and not capable of forming estrogen, it will help give a drier and harder look.
Possible side effects include male pattern baldness issues, especially if you are predisposed to it. Those that suffer with hair-loss issues will run a 5-alpha reductase inhibitor such as Finasteride or Dutasteride to counteract this side effect. DHT's can also enlarge one’s prostate if abused. Proviron is not a C-17 alpha-alkylated compound, so liver toxicity is not an issue at all.
The half-life of Proviron is 12 hours. Recommended dosage is 25-75mg per day and the detection time is 5-6 weeks. Athletes whom are tested often would be wise to avoid this compound. Females are not advised to take Proviron due to its DHT properties. Side effects for females can be very drastic, unpredictable and mostly irreversible.
Water retention: No
High blood pressure: No
Liver toxic: No
DHT Conversion: Yes, as it is a DHT derivative
Decreased HPTA function: Long term use causes suppression
Chemical Name: Mesterolone
Active life: Less than 12 hours
Drug class: Androgen and DHT derivative
Average dose: 25 – 75 mg/day